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The human pbpk model for tce and its metabolites presented here was developed by fisher et al. Physiologically based pharmacokinetic modeling and simulation. Physiologically based pharmacokinetic pbpk modeling is a mathematical modeling technique for predicting the absorption, distribution, metabolism and excretion adme of synthetic or natural chemical substances in humans and other animal species. The mu pad symbolic engine helps for symbolic computing abilities. In childhood acute lymphoblastic leukaemia, methotrexate is often combined with 6mercaptopurine and both of them have been shown to be very effective for maintenance of remission. Methotrexate is an antimetabolite and antifolate drug that is widely used in the treatment of malignancies and autoimmune disorders. The objective of this study is to develop a physiologicallybased pharmacokinetic pbpk model for each omeprazole enantiomer that accounts for nonlinear pk of the two enantiomers as well as omeprazole racemic drug.
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